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World Transplant Congress August 2006

DNA Testing allows safer use of live kidney donors at risk for autosomal dominant polycystic kidney disease (ADPKD)

Watnick et al, Baltimore

Renal ultrasound may be an adequate screening tool for potential donors older than 30, and MRI can enhance sensitivity of cyst detection. However, imaging may not provide early enough diagnosis for younger individuals, especially those from families with mild disease.

We therefore sought to lower the risk of living kidney donation in at risk donors less than 30y/o, with a negative/equivocal imaging study using DNA testing (…).

In summary, DNA testing of selected prospective live donors at risk for ADPKD increases the safety of kidney donation by decreasing the likelihood of asymptomatic disease.“

Eindeutig besagt diese Studie, dass man mit einem Gentest die Wahrscheinlichkeit einer späteren Zystennierenerkrankung testen kann. Auch besagen die Autoren eindeutig, dass die Ultraschallmethode allein nur ein Mittel für Personen über 30 ist. Hier sinkt das Risiko einer Zystennierenerkrankung.

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